Discovering cancer vulnerabilities using high-throughput micro-RNA screening

Discovering cancer vulnerabilities using high-throughput micro-RNA screening

Micro-RNAs (miRNAs) are potent regulators of gene expression and cellular phenotype. Each miRNA has the potential to target hundreds of transcripts within the cell thus controlling fundamental cellular processes such as survival and proliferation. Here, we exploit this important feature of miRNA networks to discover vulnerabilities in cancer phenotype, and map miRNA-target relationships across ...

A high-throughput screening approach to discovering

While many models of biological object recognition share a common set of ‘‘broad-stroke’’ properties, the performance of any one model depends strongly on the choice of parameters in a particular instantiation of that model—e.g., the number of units per layer, the size of pooling kernels, exponents in normalization operations, etc. Since the number of such parameters (explicit or implicit) is t...

High Throughput Screening using Membrane Chromatography

Fig. 1: Steps during process development. HTPD as a first step can help to generate a large knowledge space and improve process understanding. That advances the quality-by-design concept regarding the FDA’s (Food and Drug Administration) initiative “PharmaceuticalcGMPs for the 21 century” and ICH International Conference on Harmonisation of technical requirements for the registration of pharmac...

Discovery of novel targets with high throughput RNA interference screening.

High throughput technologies have the potential to affect all aspects of drug discovery. Considerable attention is paid to high throughput screening (HTS) for small molecule lead compounds. The identification of the targets that enter those HTS campaigns had been driven by basic research until the advent of genomics level data acquisition such as sequencing and gene expression microarrays. Larg...

Discovering contextual connections between biological processes using high-throughput data